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Particulars: Who We Are

"Don't get sick."
- Prof. John Carpenter

Kevin Dahl, Ph.D.

Founder and Lead Consultant

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Quotations, such as those peppered throughout this site, distill the wisdom of experience for those less seasoned.  Similarly, a skillful, competent consultant can condense the knowledge culled from years of practice into a resource available for rapid, professional advice.  Particlese and its founder, Kevin Dahl, aspire to improve the availability of specialized experience to partners within the pharmaceutical and biotech communities.

Kevin Dahl is an experienced scientific professional with a background in spectroscopy and microscopy.  Kevin has been involved in particle characterization for his entire commercial career, starting with ten years working alongside pharmaceutical and industrial clients at a globally recognized particle and spectroscopic instrumentation company.  This was followed by more than five years working for a contract research laboratory with small and large molecule pharmaceutical clients, where Kevin achieved the position of Director.  Kevin's experience, detailed in Analytical Specialties below, includes all of the analytical tools encountered in the modern particulate laboratory.​

Kevin began his scientific career at The Pennsylvania State University, where he studied under Professor Mark Maroncelli.  He received his Ph.D. in Physical Chemistry with a thesis titled, 'Experimental Assessment of the Effects of Solvent on the Rate of Excited State Chemical Reactions.'  His thesis work involved the use of ultrafast electronic spectroscopy to study the effects of solvent environment on intramolecular reactions.  Kevin's Ph.D. was followed by a National Science Foundation postdoctoral appointment at the U.S. Naval Research Laboratory in Washington, D.C., where ultrafast vibrational spectroscopy was used to probe the effect of solvent on molecular energy relaxation.

Analytical Specialties

Enumeration

  • Visual Inspection

  • Light Obscuration

  • Flow Microscopy

  • Static Microscopy


Particle Characterization​

  • Optical Microscopy

  • Polarized Light Microscopy

  • Raman Microspectroscopy (Morphologically-Directed Raman Spectroscopy)

  • FTIR Microspectroscopy

  • Scanning Electron Microscopy - Energy Dispersive X-ray Spectroscopy

 
Other

  • Spectral Interpretation

    • Theory and Practice

  • Bulk Raman/FTIR Spectroscopy

  • Laser Diffraction

  • Dynamic Light Scattering

  • Nanoparticle Tracking Analysis

  • Imaging Flow Cytometry

  • Spectroscopic Imaging

    • Raman​

    • FTIR

    • NIR

    • Fluorescence

Publications

Horng, M.L.; Dahl, K.; Jones II, G.; Maroncelli, M. Electron transfer in a donor-substituted acridinium dye: evidence for dynamical solvent control. Chemical Physics Letters 1999, 315(5-6).

Biswas, R.; Dahl, K.; Maroncelli, M. Rotation and Isomerization of Diphenylbutadiene and 4-(Methanol) Stilbene in Supercritical CO2 - A Re-Examination. Journal of Physical Chemistry B 2002, 106(44).

Dahl, K.; Biswas, R.; Maroncelli, M. The Photophysics and Dynamics of Diphenylbutadiene in Alkane and Perfluoroalkane Solvents. Journal of Physical Chemistry B 2003, 107(31).

Sando, G.M.; Dahl, K.; Owrutsky, J.C. Vibrational Relaxation Dynamics of Azide in Ionic and Nonionic Reverse Micelles. Journal of Physical Chemistry A 2004, 108(51).

Dahl, K.; Biswas, R.; Ito, N.; Maroncelli, M. Solvent Dependence of the Spectra and Kinetics of Excited-State Charge Transfer in Three (Alkylamino)benzonitriles. Journal of Physical Chemistry B 2005, 109(4).

Sando, G.M.; Dahl, K.; Zhong, Q.; Owrutsky, J.C. Vibrational Relaxation of Azide in Formamide Reverse Micelles. Journal of Physical Chemistry A 2005, 109(26).

Sando, G.M.; Dahl, K.; Owrutsky, J.C. Surfactant Charge Effects on the Location, Vibrational Spectra, and Relaxation Dynamics of Cyanoferrates in Reverse Micelles. Journal of Physical Chemistry B 2005, 109(9).

Dahl, K.; Sando, G.M.; Fox, D.M.; Sutto, T.E.; Owrutsky, J.C. Vibrational spectroscopy and dynamics of small anions in ionic liquid solutions. Journal of Chemical Physics 2005.

Sando, G.M.; Dahl, K.; Owrutsky, J.C. Vibrational relaxation in ionic liquids and ionic liquid reverse micelles. Chemical Physics Letters 2006, 418(4).

Sando, G.M.; Dahl, K. ; Owrutsky, J.C. Vibrational Spectroscopy and Dynamics of Azide Ion in Ionic Liquid and Dimethyl Sulfoxide Water Mixtures. Journal of Physical Chemistry B 2007.

[LINK] Pardeshi, N. N.; Qi, W.; Dahl, K.; Caplan, L.; Carpenter, J. F. Microparticles and Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product. Journal of Pharmaceutical Sciences 2017, 106(2).

[LINK] Sutton, M.J.; Osborne, D.W.; Dahl, K.; Bax, V.; Schick, G.A. (2018). Characterization of a Liquid Crystal Stabilized Pharmaceutical Oil-in-Water Emulsion Optimized for Skin Delivery. Journal of Cosmetics, Dermatological Sciences and Applications 2018, 8, 207.

Osborne, D.W.; Dahl, K.; Parikh, H. 2019. Determination of particle size and microstructure in topical pharmaceuticals. In The Role of Microstructure in Topical Drug Product Development, 2019, 89. Springer.

Schack, M.M.; Dahl, K.; Rades, T.; Groenning, M.; Carpenter, J.F. Spectroscopic Evidence of Tertiary Structural Differences Between Insulin Molecules in Fibrils. Journal of Pharmaceutical Sciences, 2019, 108(9).

[LINK] Jean-Baptiste, T.; Carpenter, J.F.; Dahl, K.; Derameau, W.; Veillard, R.; Jacquet, J.R.; Osselyn, P.L.; Figueras, A. Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti. Antibiotics 2020, 9, 407. 

Presentations

K. Dahl, G.M. Sando, and J.C. Owrutsky, FTIR and Ultrafast Infrared Spectroscopy of the Dicyanamide Anion in Solution, International Symposium on Molecular Spectroscopy, 2005.

K. Dahl, G.M. Sando, and J.C. Owrutsky, Ultrafast Infrared Studies of the Vibrational Relaxation Dynamics of Anion in Ionic Liquids, International Symposium on Molecular Spectroscopy, 2005.

K. Dahl, W. Qi, L. Kidder, K.S. Haber, and E.N. Lewis, Raman Spectroscopy Paired with Dynamic Light Scattering: Probing Higher-order Structure of Protein Biotherapeutics, SCIX 2014.

K. Dahl and A. Fradkin, Workshop on Particle Characterization, 2018 Colorado Protein Stability Conference, Breckenridge, CO, 2018.

K. Dahl, Particulate Epiphanies, Formulation and Drug Delivery US, 2019.K. Dahl, Workshop on Particle Characterization, Formulation and Drug Delivery UK, 2019.

K. Dahl, L. Kidder, High Sensitivity Tools for Vaccine Development and Quality, Webinar, 2022.

K. Dahl, Session Chair: Engineering Better Protein Therapeutics, 2022 Colorado Protein Stability Conference, Breckenridge, CO, 2022.

K. Dahl, Lilliputian Particles: Scattering and Spectroscopy Applied to New Large Molecule Delivery Vehicles, 2022 Sci-X Meeting, Covington, KY, 2022.

Affiliations

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